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Designer Benzodiazepines: A Review of Toxicology and Public Health Risks PMC

Categoría del post Sober living Fecha de publicación de la noticia

what is clonazolam

They may also be used by people who are addicted to benzodiazepines and who cannot get them legally from their healthcare providers. Mental health disorders are another common risk factor for illicit drug use, as people with mental illnesses may use drugs like clonazolam to reduce or escape their symptoms. Data for other benzodiazepines suggest the possibility of long-term effects on neurobehavioral and immunological function in animals following prenatal exposure to benzodiazepines at clinically relevant doses.

what is clonazolam

What are clonazepam tablets’ side effects?

For most NPS placed under international control, the number of reports decreased rapidly the year after the scheduling decision [150]. However, for flualprazolam, phenazepam, flubromazolam and etizolam, enforcement was delayed two, five, seven and nine years, respectively, after formal notification [73]. 6-(2-Chlorophenyl)-1-methyl-8-nitro-4H-[1,2,4]triazolo[4,3-a][1,4]benzodiazepine, also known as clonitrazolam, is the triazolo-analogue of clonazepam [1,129]. Clonazolam is described as “insanely powerful”, producing strong sedation and amnesia at oral doses as low as 0.5 mg, resulting in easy accidental overdose [78].

Clonazolam Withdrawal

Place the tablet in your mouth and allow it to dissolve, without chewing. Some people have thoughts about suicide while taking clonazepam. Your family or caregivers should also watch for sudden changes in your behavior. For more information on tapering from benzodiazepines in a controlled manner, please see this guide. https://sober-home.org/alcohol-addiction/ Small quantities of alcohol can also help to reduce the symptoms, but otherwise cannot be used as an effective tapering agent. Clonazolam is reported to be similar to alprazolam and other benzodiazepines that suppress emotions and produce moderate-strong feelings of relaxation, pleasure and comfort in the body.

5. Etizolam

This seems to present itself more often in those with pre-existing anxiety. Many anecdotal reports from users of this compound have stated it as being one of the most euphoric benzodiazepines. Ingestion of raw clonazolam powder is unsafe due to its microgram-range potency and the ease in which it can lead to multi-day blackouts. The therapeutic range of clonazepam is from 0.02 to 0.08 mcg/mL. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

What Is Medical Detox, and How Does it Help With Clonazolam Withdrawal?

Like most drugs, clonazepam tablets may cause mild and serious side effects. The lists below describe some of the more common side effects that clonazepam tablets may cause. Clonazepam is used alone or in combination with other medications to control certain types of seizures.

Cytochrome P-450 including CYP3A, may play an important role in clonazepam reduction and oxidation. The elimination half-life of clonazepam is typically 30 to 40 hours. Clonazepam pharmacokinetics are dose-independent throughout the dosing range. There is no evidence that clonazepam induces its own metabolism or 2c drug effects of 2c that of other drugs in humans. Clinical studies of Klonopin did not include sufficient numbers of subjects aged 65 and over to determine whether they respond differently from younger subjects. Other reported clinical experience has not identified differences in responses between the elderly and younger patients.

The effectiveness of Klonopin in long-term use, that is, for more than 9 weeks, has not been systematically studied in controlled clinical trials. The physician who elects to use Klonopin for extended periods should periodically reevaluate the long-term usefulness of the drug for the individual patient (see DOSAGE AND ADMINISTRATION). Klonopin can slow or stop your breathing, especially if you have recently used an opioid medication, alcohol, or other drugs that can slow your breathing.

Addiction is characterized by a set of compulsive behaviors related to drug use that is difficult to control. For example, you may be addicted to clonazolam if you skip work or school to use this drug, or if you keep using it even though you know it is causing other health problems, like depression or lung dysfunction. KLONOPIN can also make your seizures happen more often or make them worse. Call dandruff symptoms and causes your healthcare provider right away if your seizures get worse while taking KLONOPIN. Controlled studies examining the influence of gender and age on clonazepam pharmacokinetics have not been conducted, nor have the effects of renal or liver disease on clonazepam pharmacokinetics been studied. Thus, caution should be exercised when administering clonazepam to these patients (see CONTRAINDICATIONS).

  1. This medicine may be used for other purposes; ask your health care provider or pharmacist if you have questions.
  2. Clonazepam works by increasing the activity of gamma aminobutyric acid (GABA).
  3. Sharing this information can help avoid potential interactions.
  4. Clonazepam (Klonopin) and lorazepam (Ativan) are prescription drugs that are available in both generic and brand-name versions.
  5. In these nine cases [92,95,97], etizolam was detected in peripheral blood at concentrations of 1–237 ng/mL.

Follow your doctor’s orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so. Drug rehab programs use a variety of therapies to address the root causes of your addiction and help you achieve long-term recovery.

Rehab programs usually last between 30 and 90 days, though 120-day programs are also available for those who need more time in which to recover from drug misuse. The clonazolam you use may produce additional effects than those mentioned above, especially if it is mixed with other substances like opioids and stimulants. The effects of clonazolam can be unpredictable, as the type of ingredients and their amounts may vary from one batch to the next. Avoid using any clonazolam at all if possible, as you will never know exactly what is in this drug if you are buying it from dealers on the street. Clonazolam is a benzodiazepine derivative, or designer benzodiazepine.

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